Clyde is absent minded, forgetful, clumsy and not very smart. He prefers action and being useful and support to his friends.
Stan: Clyde and Stan do not interact much, and their actual relationship is unknown. Stan tries to save Clyde from Lenny in Riot, but Clyde took his death as a gift, not wanting to deal with the Riots and Chaos. Stan fights with Lenny after doing so.
Kyle: Clyde and Kyle do not interact much, and their relationship is unknown. It is possible he was appointed Co Leader as an act of jealousy of Craig; due to
Stan and Kyle's relationship and of Kyle becoming Co Leader.
Kenny: Clyde and Kenny do not interact much, and their actual relationship is unknown. Their major interaction is in The Walking Dead, when Cartman shoots Clyde and Kenny attempts to save him, but fails and watches in horror as he is devoured. He also nearly killed Cartman for doing so.
Cartman: Clyde and Cartman do not interact much and their actual relationship is unknown. Their major interaction is in The Walking Dead, when he is shot by Cartman in a sacrifice attempt for so he can escape, and Kenny attempts to save him, but is unable to, and assaults Cartman and almost kills him, but gives him another chance.
Craig: Craig and Clyde are great friends, and their relationship is like Stan and Kyle's, and he is appointed Co Leader by Craig, as a possible jealousy of Stan and Kyle's friendship and appointment of Kyle as Co Leader. Craig is furious with Lenny after he intentionally killed Clyde in Riot, and was later gunned down himself by Lenny (Along with Stan) and Clyde is avenged by a headshot to Lenny, from his best friend, Craig, who fell down and died of blood loss from the gunfight.
Nix: Clyde and Nix do not interact much and their relationship is unknown.
Lenny: Lenny and Clyde do not interact much and their actual relationship is unknown. Lenny points a gun at Clyde in Riot, and ignores Stan, who attempts to stop him from killing Clyde and proceeds the "deed" and seems happy to kill his friend, and is beaten by Stan and later killed by Craig, only for him to fall down and die of bloodloss from the shooting.